AMIKACIN SULPHATE INJECTION I.P. ( INJECTIONS ) Manufacturer | Supplier | Franchise

Amigud 500 is the brand name of Amikacin sulphate injection manufactured by Medxone . This injection is widely used in the treatment of serious bacterial infections. These injections are mostly used in clinics and hospitals. The high effectiveness of the injection and its track record have made it one of the trusted and top choices of healthcare professionals. The type of infections in which this injection is used are Respiratory tract infections, Urinary tract infections, Intra-abdominal infections, Septicemia, Bone and joint infections, Skin and soft tissue infections, and Central nervous system infections. 

Mechanism of Action 

Amikacin, the active ingredient in AMIGUD 500, belongs to the aminoglycoside class of antibiotics. It works by binding irreversibly to the 30S ribosomal subunit of bacterial cells, inhibiting protein synthesis. This disruption in protein production results in bacterial cell death, making the drug bactericidal rather than bacteriostatic. Amikacin is particularly effective against resistant strains of Pseudomonas aeruginosa, Escherichia coli, Klebsiella, Proteus, and Enterobacter species, which are often responsible for severe infections. Its strong activity against multidrug-resistant organisms gives it a critical role in modern antimicrobial therapy.

Indication for the Use of Amigud-500

Here are some of the conditions in which this injection is indicated to be used: 

• Respiratory tract infections 
• Urinary tract infections (UTIs)
• Intra-abdominal infections
• Septicemia (bloodstream infections).
• Bone and joint infections 
• Skin and soft tissue infections
• Central nervous system infections

Dosage and Administration 

The injection is always preferred to be taken as prescribed by the doctor; self-medication can be risky. Some of the common doses that a doctor recommends are : 

For Adults, the recommended dose of the injection is 15 mg/kg/day divided into 2–3 equal doses administered intramuscularly (IM) or intravenously (IV).
For Children, the dose is based on body weight and clinical condition, usually 15–20 mg/kg/day in divided doses.

Possible Side Effects 

Here are some of the Possible Side effects that can be visible during the administration. If these symptoms persist and cause more problems, consult your doctor as soon as possible. 

• Nephrotoxicity (kidney dysfunction).
• Ototoxicity (hearing loss, ringing in the ears, or balance issues).
• Injection site pain or irritation.
• Neuromuscular blockade in rare cases.
• Allergic reactions such as rash, itching, or swelling.

Precautions to be Followed 

Here are some of the precautions that must be followed while administering the injection for an effective treatment : 

• This injection must only be used when prescribed and under medical supervision.
• Patients with pre-existing renal impairment or hearing disorders should be treated with caution.
• Avoid concurrent use with other nephrotoxic or ototoxic drugs unless necessary.
• Pregnant women should use AMIGUD 500 only if clearly needed and prescribed by a physician.
• Adequate hydration is recommended to reduce the risk of kidney damage.
• Regular monitoring of renal function, serum drug levels, and auditory function is essential during therapy.

Storage Information 

• Must be stored in a cool and dry storage 
• The packaging must not be broken 
• Keep away from direct sunlight 
• Keep out of reach of children.